E-BOSS: An Extensive stellar BOw Shock Survey. II. Catalogue second release

Context. Stellar bow shocks have been studied not only observationally, but also theoretically since the late 1980s. Only a few catalogues of them exist. The bow shocks show emission along all the electromagnetic spectrum, but they are detected more easily in infrared wavelengths. The release of new and high-quality infrared data eases the discovery and subsequent study of new objects. Aims. We search stellar bow-shock candidates associated with nearby runaway stars, and gather them together with those found elsewhere, to enlarge the list of the E-BOSS first release. We aim to characterize the bow-shock candidates and provide a database suitable for statistical studies. We investigate the low-frequency radio emission at the position of the bow-shock features, that can contribute to further studies of high-energy emission from these objects. Methods. We considered samples from different literature sources and searched for bow-shaped structures associated with stars in the Wide-field Infrared Survey Explorer (WISE) images. We looked for each bow-shock candidate on centimeter radio surveys. Results. We reunited 45 bow-shock candidates and generated composed WISE images to show the emission in different infrared bands. Among them there are new sources, previously studied objects, and bow shocks found serendipitously. Five bow shocks show evidence of radio emission. Conclusions. Stellar bow shocks constitute an active field with open questions and enormous amounts of data to be analyzed. Future research at all wavelengths databases, and use of instruments like Gaia, will provide a more complete picture of these objects. For instance, infrared spectral energy distributions can give information about physical parameters of the bow shock matter. In addition, dedicated high-sensitivity radio observations can help to understand the radio-$\gamma$ connection.Comment: 20 pages, 11 figures, and 8 tables. Accepted for publication in A&

Organocatalytic Michael addition to (D)-mannitol-derived enantiopure nitroalkenes: A valuable strategy for the synthesis of densely functionalized chiral molecules

Carbohydrates are abundant renewable resources and are a feedstock for green chemistry and sustainable synthesis of the future. Among the hexoses and the pentoses present in biomass, mannitol was selected in the present project as a valuable platform, directly available from the chiral pool, to build highly functionalized molecules. Starting from (R)-2,3-O-cyclohexylidene glyceraldehyde, which is easily prepared in a large scale from D-mannitol, an enantiopure chiral nitro alkene was prepared by reaction with nitromethane, and its reactivity studied. Organocatalytic Michael addition of dimethyl malonate, \u3b2-keto esters, and other nucleophiles on the nitro alkene afforded high stereoselectivity and densely functionalized chiral molecules, which were further synthetically developed, leading to five-membered lactones and bicyclic lactams. Preliminary studies showed that the metal-free catalytic reaction on the chiral nitro alkene can be performed under continuous flow conditions, thus enabling the use of (micro)mesofluidic systems for the preparation of enantiomerically pure organic molecules from the chiral pool

Evaluation of In-Batch and In-Flow Synthetic Strategies towards the Stereoselective Synthesis of a Fluorinated Analogue of Retro-Thiorphan

A stereoselective synthetic strategy for the preparation of trifluoromethylamine mimics of retro-thiorphan, involving a diastereoselective, metal-free catalytic step, has been studied in batch and afforded the target molecule in good yields and high diastereoselectivity. A crucial point of the synthetic sequence was the catalytic reduction of a fluorinated enamine with trichlorosilane as reducing agent in the presence of a chiral Lewis base. The absolute configuration of the key intermediate was unambiguously assigned by X-ray analysis. The synthesis was also investigated exploiting continuous flow reactions; that is, an advanced intermediate of the target molecule was synthesized in only two in-flow synthetic modules, avoiding isolation and purifications of intermediates, leading to the isolation of the target chiral fluorinated amine in up to an 87:13 diastereoisomeric ratio

The Rapid Growth of Fibroids during Early Pregnancy

Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized that this phenomenon may mainly occur during initial pregnancy. To test this hypothesis, we set up a prospective cohort study of women with fibroids undergoing IVF. Cases were women achieving a viable pregnancy. Controls were the subsequent women with fibroids but failing to become pregnant. Twenty-five cases and 25 controls were recruited. The total number of fibroids in the two groups was 46 and 41, respectively. The mean \ub1 SD diameter of the fibroids was 17 \ub1 10 and 20 \ub1 11 mm, respectively (p = 0.18). A statistically significant enlargement emerged exclusively in pregnant women. The median (Interquartile Range) modification of the diameter of the lesions in cases and controls was +34% (+6%/+65%) and +2% (-6%/+12%), respectively (p<0.001). The median (Interquartile Range) modification of the volume of the lesions was +140% (+23%/+357%) and 0% (-18%/+37%), respectively (p<0.001). In pregnant women, we failed to document any significant correlation between the magnitude of the growth and ovarian responsiveness to hyper-stimulation, suggesting that steroids hormones are not the unique factors involved. In conclusion, fibroids undergo a rapid and remarkable growth during initial pregnancy. Reasons behind this phenomenon remain to be clarified. The early rise in steroids hormones during early pregnancy may not be sufficient to explain the process. Other pregnancy-related hormones and proteins may play also key roles

The impact of IVF on deep invasive endometriosis

Objective: Ovarian hyper-stimulation during IVF is associated with a significant raise in serum estrogens and one may expect detrimental effects on estrogen-dependent diseases such as endometriosis. However, available evidence from large case series of affected women performing IVF is generally reassuring with the possible exception of women carrying deep invasive lesions. On this basis we deemed important investigating more in depth whether women with deep invasive endometriosis could be a subgroup at higher risk of recurrence or disease progression during IVF. Study design: Women with endometriosis who underwent IVF and who had a second evaluation after 3\u20136 months from a failed cycle were retrospectively reviewed. The main inclusion criteria were the presence of deep invasive endometriosis and/or a history of surgery for this form of the disease. The primary aim of the study was to determine the frequency of endometriosis-related complications in the interval between the two evaluations. Secondary aims were pain symptoms and lesion size modifications. Results: Eighty-four women were ultimately selected: baseline ultrasound documented deep invasive lesions in 60 of them. One case of possible endometriosis-related complication was recorded, corresponding to a rate of 1.2% (95%: 0.05%\u20135.5%) for the whole cohort and 1.7% (95%CI: 0.08\u20137.6%) for the subgroup of women with ultrasound detected lesions. This rate appears similar to the reported frequency of endometriosis progression in women not receiving IVF. No significant modifications in pain symptoms or lesions size occurred. Conclusions: Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion

Ovarian stimulation and endometriosis progression or recurrence: a systematic review

Available evidence on the impact of ovarian stimulation on the progression of endometriosis or its recurrence was systematically reviewed. Data from ovarian stimulation alone, or associated with intrauterine insemination (IUI) or IVF, were included. Sixteen studies were selected. Initial case reports (n = 11) documented some severe clinical complications. However, subsequent observational studies were more reassuring. Overall, five conclusions can be drawn: (i) IVF does not worsen endometriosis-related pain symptoms (moderate quality evidence); (ii) IVF does not increase the risk of endometriosis recurrence (moderate quality evidence); (iii) the impact of IVF on ovarian endometriomas, if present at all, is mild (low quality evidence); (iv) IUI may increase the risk of endometriosis recurrence (low quality evidence); (v) deep invasive endometriosis might progress with ovarian stimulation (very low quality evidence). In conclusion, available evidence is generally reassuring (at least for IVF) and does not justify aggressive clinical approaches such as prophylactic surgery before assisted reproductive technology treatment to prevent endometriosis progression or recurrence. However, further evidence is required before being able to reach definitive conclusions. In particular, the potential effects on deep invasive endometriosis and the possible synergistic effect of stimulation and pregnancy are two areas that need to be explored further

Non-thermal emission from star-forming galaxies detected in gamma rays

Star-forming galaxies (SFGs) emit non-thermal radiation from radio to gamma-rays. We aim to investigate the main mechanisms of global CR transport and cooling in SFGs. The way they contribute in shaping the relations between non-thermal luminosities and SFR could shed light onto their nature. We develop a model to compute the CR populations of SFGs, taking into account their production, transport, and cooling. The model is parameterised only through global galaxy properties, and describes the non-thermal emission in both radio and gamma-rays. We focus on the role of diffusive and advective transport by galactic winds, either driven by turbulent or thermal instabilities. We compare model predictions to observations, for which we compile a homogeneous set of luminosities in these radio bands, and update those available in gamma-rays. Our model reproduces reasonably well the observed relations between the gamma-ray or 1.4 GHz radio luminosities and the SFR, assuming a single power-law scaling of the magnetic field with the latter with index beta=0.3, and winds blowing either at Alfvenic speeds or typical starburst wind velocities. Escape of CR is negligible for > 30 Mo/yr. A constant ionisation fraction of the interstellar medium fails to reproduce the 150 MHz radio luminosity throughout the whole SFR range. Our results reinforce the idea that galaxies with high SFR are CR calorimeters, and that the main mechanism driving proton escape is diffusion, whereas electron escape also proceeds via wind advection. They also suggest that these winds should be CR or thermally-driven at low and intermediate SFR, respectively. Our results globally support that magnetohydrodynamic turbulence is responsible for the dependence of the magnetic field strength on the SFR and that the ionisation fraction is strongly disfavoured to be constant throughout the whole SFR range.Comment: Submitted to Astronomy & Astrophysics (on 12/05/2021

The impact of endometrioma size on ovarian responsiveness

Research question: Available evidence shows that the presence of ovarian endometriomas does not interfere with the ovarian response to ovarian stimulation. However, the mean size of the endometriomas in these studies is generally small, and two recent investigations suggested that follicular development could be impaired when focusing on larger endometriomas. However, these studies could not identify a clear threshold above which endometriomas could become detrimental. Design: To identify this threshold, the study retrospectively selected women without a history of surgery for ovarian cysts who underwent IVF in the presence of unilateral endometriomas with a mean diameter between 20 and 49 mm. Selected women were divided into three categories of endometrioma size: 20-29 mm (group 1, n = 23), 30-39 mm (group 2, n = 2323), and 40-49 mm (group 3, n = 2321). Recruitment for each category was censored at about 21 women to ensure equal statistical power for each group. Results: The response to ovarian stimulation was equal or superior in the affected gonads in eight women (35%, 95% confidence interval [CI] 16-57%), seven women (30%, 95% CI 13-53%) and two women (10%, 95% CI 2-30%) in groups 1, 2 and 3, respectively. The median (interquartile range) number of developed follicles in the affected and intact ovaries was 6 (3-7) and 5 (4-9) in group 1 (P = 0.21), 4 (1-6) and 4 (3-7) in group 2 (P = 0.08), 5 (3-7), and 7 (4-8) in group 3 (P = 0.01), respectively. Conclusions: The threshold to be used to distinguish between endometriomas that might and might not interfere with ovarian response is 4 cm in diameter

E-BOSS: an Extensive stellar BOw Shock Survey. I: Methods and First Catalogue

Context: Bow shocks are produced by many astrophysical objects where shock waves are present. Stellar bow shocks, generated by runaway stars, have been previously detected in small numbers and well-studied. Along with progress in model development and improvements in observing instruments, our knowledge of the emission produced by these objects and its origin can now be more clearly understood. Aims: We produce a stellar bow-shock catalogue by applying uniform search criteria and a systematic search process. This catalogue is a starting point for statistical studies, to help us address fundamental questions such as, for instance, the conditions under wich a stellar bow shock is detectable. Methods: By using the newest infrared data releases, we carried out a search for bow shocks produced by early-type runaway stars. We first explored whether a set of known IRAS bow shock candidates are visible in the most recently available IR data, which has much higher resolution and sensitivity. We then carried out a selection of runaway stars from the latest, large runaway catalogue available. In this first release, we focused on OB stars and searched for bow-shaped features in the vicinity of these stars. Results: We provide a bow-shock candidate survey that gathers a total of 28 members which we call the Extensive stellar BOw Shock Survey (E-BOSS). We derive the main bow-shock parameters, and present some preliminary statistical results on the detected objects. Conclusions: Our analysis of the initial sample and the newly detected objects yields a bow-shock detectability around OB stars of $\sim$ 10 per cent. The detections do not seem to depend particularly on either stellar mass, age or position. The extension of the E-BOSS sample, with upcoming IR data, and by considering, for example, other spectral types as well, will allow us to perform a more detailed study of the findings.Comment: A&A accepted (25-NOV-2011), 15 pages, 4 tables, 11 figure

New evidence on the origin of the microquasar GRO J1655-40

Aims. Motivated by the new determination of the distance to the microquasar GRO J1655-40 by Foellmi et al. (2006), we conduct a detailed study of the distribution of the atomic and molecular gas, and dust around the open cluster NGC 6242, the possible birth place of the microquasar. The proximity and relative height of the cluster on the galactic disk provides a unique opportunity to study SNR evolution and its possible physical link with microquasar formation. Methods. We search in the interstellar atomic and molecular gas around NGC 6242 for traces that may have been left from a supernova explosion associated to the formation of the black hole in GRO J1655-40. Furthermore, the 60/100 mu IR color is used as a tracer of shocked-heated dust. Results. At the kinematical distance of the cluster the observations have revealed the existence of a HI hole of 1.5*1.5 degrees in diameter and compressed CO material acumulated along the south-eastern internal border of the HI cavity. In this same area, we found extended infrared emission with characteristics of shocked-heated dust. Based on the HI, CO and FIR emissions, we suggest that the cavity in the ISM was produced by a supernova explosion occured within NGC 6242. The lower limit to the kinematic energy transferred by the supernova shock to the surrounding interstellar medium is ~ 10^{49} erg and the atomic and molecular mass displaced to form the cavity of ~ 16.500 solar masses. The lower limit to the time elapsed since the SN explosion is ~ 2.2*10^{5} yr, which is consistent with the time required by GRO J1655-40 to move from the cluster up to its present position. The observations suggest that GRO J1655-40 could have been born inside NGC 6242, being one of the nearest microquasars known so far.Comment: 6 pages, 6 figures. Accepted for publication in Astronomy & Astrophysic